java.lang.RuntimeException: Connection refused
Workflow notification mailer not starting after auto config run on ebs 12.1.
check your workflow notification mailer as advanced tab, can you able to reach the outbound and inbound server. If not, check outbound email server name with port and inbound server name with port. If those information was correct, Still you have issue then Can you try to reach the outbound and inbound servers with port from application servers.